Attività Scientifica

La Fondazione Futura-onlus ha contribuito al finanziamento di diversi progetti di ricerca scientifica nell’area biomedica. Di seguito sono elencati i lavori scientifici pubblicati su importanti riviste internazionali in cui il contributo dell’ Associazione Futura-Onlus è stato ufficialmente riconosciuto.

 1) Baldi A., Battista T., De Luca A., Santini D., Rossiello R., Baldi F., Natali P.G., Lombardi D., Picardo M., Felsani A., Paggi M.G. (2003): Identification of genes down-regulated during melanoma progression: a cDNA array study. Experimental Dermatology 12: 213-218                                    

2) Abbate A., Biondi-Zoccai G.G.L., Bussani R., Dobrina A., Camilot D, Feroce F., Rossiello R., Baldi F., Silvestri F., Biasucci L.M., Baldi A (2003): Increased myocardial apoptosis in patients with unfavorable left ventricular remodeling and early symptomatic post-infarction heart failure. Journal of American College of Cardiology  41: 753-60
                            
3) Tonini G, Vincenzi B, Santini D, Avvisati G, La Cesa A, Baldi A (2003): Clinical complete response of a large cutaneous local recurrence from breast cancer after Trastuzumab base immunotherapy. Journal of Clinical Oncology 21: 2215-2216.        

3) Baldi A., Santini D., De Luca A., Paggi M.G. (2003) cDNA array technology in melanoma: an overview. Journal of Cellular Physiology 196: 219-223                                            

4) De Luca A., Mangiacasale R., Severino A., Malquori L., Baldi A., Palena A., Mileo A.M., Lavia P., Paggi M.G. (2003): E1A deregulates the centrosome cycle in a Ran GTPase-dependent manner. Cancer Research 63: 1430-1437.                

5) Tonini G., Vincenzi B., Santini D., La Cesa A., Finolezzi E., Onori R., D’Angelillo R., Baldi A., Trodella L. (2003): Prevention of radiotherapy-induced emesis. Journal of Experimental & Clinical Cancer Research 22: 17-22.                    
    
6) Baldi A., Persichetti P., Di Marino M.P., Nicoletti G., Baldi F. (2003): Pleomorphic adenoma of cervical heterotopic salivary glands. Journal of Experimental & Clinical Cancer Research 22: 645-647.                            

7) Groeger A.M., Esposito V., De Luca A., Cassandro R., Tonini G., Ambrogi V., Baldi F., Goldfarb R., Mineo T.C., Baldi A., Wolner E. (2004): Prognostic value of immunohistochemical expression of p53, BAX, BCL-2 and BCL-Xl in resected non small cell lung cancer. Histopathology 44: 54-63.                                        

8) De Luca A., De Falco M, Severino A, Campioni M, Santini D, Baldi F, Paggi MG, Baldi A (2003) Distribution of the Serine Protease HtrA1 in Normal Human Tissues. Journal of  Hystochemistry and Cytochemistry 51:1279-84                

9) Abbate A., Biondi-Zoccai G.G.L., Bussani R., Camilot D., Dobrina A., Leone A.M., Baldi F., Silvestri F., Biasucci L.M., Baldi A. (2003) High-risk clinical features predict increased post-infarction myocardial apoptosis and the benefits as a result of an open infarct-related artery. European Journal of Clinical Investigation 33:662-8                            

10) Abbate A., Biondi-Zoccai G.G.L., Bussani R., Dobrina A., Leone A.M., Camilot D., Di Marino M.P., Baldi F., Silvestri F., Biasucci L.M., Baldi A. (2003): Right ventricular dilatation after left ventricular acute myocardial infarction is predictive of extremely high peri-infarctual apoptosis at postmortem examination in humans . Journal of Clinical Pathology 56:672-6.                

11) Esposito V., Baldi A., Vincenzi B., Tonini G., Santini M., Ambrogi V., Persichetti P., Mineo T.C., Baldi F., Groeger A.M. (2004) Analysis of cell cycle regulator proteins in non-small cell lung cancer.  Journal of Clinical Pathology  57: 58-63            

12) Baldi A., Di Marino MP, Persichetti P, Ferrara N, Baldi F (2003): Cystitis glandularis complicating an eosinophilic cystitis: a case report. In Vivo 17: 651-653.                                            

13) Esposito V, Baldi A, Liuzzi G, Tonini G, Vincenzi B, Persichetti P, Santini M, Ambrogi V, Mineo TC, Montesarchio V, Wolner E, Baldi F, Groeger AM (2003): Analysis of Fas (Apo-1/CD95) expression in non-small-cell lung cancer. Anticancer Research 23: 4901-4905.    

14) Baldi A., Di Marino M.P., Nicoletti G., Colella G., Persichetti P. (2004): Embryonal rabdomyosarcoma of the tongue in old age. Oral Pathology 40: 450-452.                                            

15) Baldi A., Santini D., Russo P., Catricalà C., Amantea A., Picardo M., Tatangelo F., Botti G., Dragonetti E., Murace R., Tonini G., Natali P.G., Baldi F., Paggi M.G. (2004): Analysis of APAF-1 expression in human melanoma. Experimental Dermatology 13: 93-97    

16) Abbate A., Santini D., Biondi-Zoccai G.L., Scarpa S., Vasaturo F., Liuzzo G., Bussani R., Silvestri F., Baldi F., Crea F., Biasucci L.M., Baldi A. (2004): Cyclooxygenase-2 (Cox-2) expression at site of recent myocardial infarction: friend or foe?. Heart  90: 440-443            

17) Biondi-Zoccai G.L., Abbate A., Vasaturo F., Scarpa S., Leone A.M., Parisi Q., De Giorgio F., Bussani R., Silvestri F., Baldi F., Biasucci L.M., Baldi A. (2004): Increased apoptosi in remote non-infarcted myocardium in multivessel coronary disease. International Journal of Cardiology 94: 105-110                                    

18) Abbate A., Biondi-Zoccai G.L., Leone A.M., Bussani R., Camilot D., Bassan F., Silvestri F., Baldi F., Baldi A. (2004): PCNA expression in ischemic cardiomyopathy: DNA repair, myocyte regeneration or just another type of myocyte death? International Journal of Cardiology 97: 153-154.                                                
19) Baldi A,, Santini D, Vasaturo F, Santini M, Vicidomini G, Di Marino MP, Esposito V, Groeger AM, Liuzzi G, Vincenzi B, Tonini G, Piccoli M, Baldi F, Scarpa S (2004): Prognostic significance of cyclooxygenase-2 (COX-2) and expression of cell cycle inhibitors p21 and p27 in human pleural malignant mesothelioma. Thorax 59: 428-433                                

20) De Luca A, De Falco M, Fedele V, Cobellis L, Mastrogiacomo A, Laforgia V, Tuduce IL, Campioni M, Giraldi D, Paggi MG, Baldi A (2004): The serine protease HtrA1 is upregulated in the human placenta during pregnancy. Journal of  Hystochemistry and Cytochemistry 52: 885-892                                                    
21) Baldi A, De Falco M, De Luca L, Cottone G, Paggi MG, Nickoloff BJ, Miele L, De Luca A (2004): Characterization of tissue specific expression of Notch-1 in human tissues.  Biology of the Cell 96: 303-311                        

22) Parisi Q, Biondi-Zoccai GL, Abbate A, Santini D, Vasaturo F, Scarpa S, Bussani R, Leone AM, Petrolini A, Silvestri F, Biasucci LM, Baldi A (2004): Hypoxia inducible factor-1 expression mediates myocardial response to ischemia later after acute myocardial infarction. International Journal of Cardiology (in press).                                        

23) Baldi A, Santini M, Mellone P, Esposito V, Groeger AM, Caputi M, Baldi F (2004): Mediastinal hibernoma, a case report. Journal of Clinical Pathology 57: 993-994                                        

24) Persichetti P, Di Lella F, Marangi GF, Cagli B, Simone P, Tenna S, Rabitti C, Cassandro R, Esposito V, Groeger AM, Baldi A (2004) Pleomorphic lipoma : a definitive histopathological entity. Anticancer Research 24: 3157-3159                

25) Persichetti P, Di lella F, Marangi GF, Cagli B, Simone P, Tenna S, Cogliandro A, Ambrosino F, Esposito V, Groeger AM, Baldi A (2004) Leiomyosarcoma of the scrotum arising from the dartos muscle: a rare clinicopathological entity. In Vivo  18: 553-554        

26) Dragonetti E, Cianchini G, Mastrangelo L, Mellone P, Baldi A (2004) Cutaneous pseudolymphoma: a case report. In Vivo 18: 549-551    
                                            
27) Noonan DM, Severino A, Morini M, Tritarelli A, Manente L, D’Agnano I, Storace G, Baldi A, Lombardi D, Albini A, Felsani A, Paggi MG (2004) In vitro and in vivo tumor growth inhibition by a p16-mimicking peptide in p16-defective, pRb-positive human melanoma cells. Journal of Cellular Physiology (in press)                                            

28) Santini D, Abbate A, Scarpa S, Vasaturo F, Biondi-Zoccai GGL, De Giorgio F, Bassan F, Camilot D, Di Marino MP, Baldi F, Silvestri F, Crea F, Baldi A (2004): Surviving acute myocardial infarctions, survivin expression in viable cardiomyocites after infarction. Journal of Clinical Pathology
57: 1321-1324                                        

29) De Luca A, De Falco M, De Luca L, Penta R, Shrijdar V, Baldi F, Campioni M, Paggi MG, Baldi A (2004): Pattern of expression of HtrA1 during mouse development.  Journal of  Hystochemistry and Cytochemistry 52: 1609-1617                    
    
30) Biondi-Zoccai GGL, Abbate A, Bussani R, Camilot D, Di Giorgio F, Di Marino MP, Silvestri F, Baldi F, Biasucci LM,  Baldi A (2005): Reduced post-infarction myocardial apoptosis in women: a clue to their different clinical course? Heart 91: 99-101.

31) Baldi A., Lombardi D, Russo P, Palescandolo E, De Luca A, Santini D, Baldi F, Rossiello L, Dell’Anna ML, Mastrofrancesco A, Maresca V, Flori E, Natali PG, Picaro M, Paggi MG (2005): Ferritin contributes to melanoma progression by modulating cell growth and sensitivity to oxidative stress. Clinical Cancer Rsearch Clinical Cancer Research 11: 3175-3183.

32) Esposito V, Baldi A, De Luca A, Tonini G, Vincenzi B, Santini D, Persichetti P, Mancini A, Citro G, Baldi F, Groeger AM, Caputi M (2005):  Cell cycle related proteins as prognostic parameters in radically resected non small cell lung cancer (NSCLC). Journal of Clinical Pathology  58: 734-739                    

33) Grau S, Baldi A, Bussani R, Tian X, Stefanescu R, Przyblyski M, Richards P, Jones SA, Shridhar V, Clausen T, Ehrmann M (2005): Implications of the serine protease HtrA1 in amyloid precursor protein processing. Proceeding of the National Academy of Science, USA. 102: 6021-6026.                        

34) Baldi A, Ambrogi V, Mineo D, Mellone P, Campioni M, Citro G, Mineo TC (2005): Analysis of cell-cycle regulator proteins in encapsulated thymomas. Clinical Cancer Research 11: 1-6            

35) Cardillo I, Spugnini EP, Verdina A, Galati R, Citro G, Baldi A (2005): Cox and mesothelioma, an overview. Histology and Histopathology 20: 1267-1274                            

36) Spugnini EP, Porrello A, Citro G, Baldi A (2005) Cox-2 overexpression in canine tumors, potential therapeutic targets in oncology. Histology and Histopathology 20: 1309-1312                    
                            
37) Persichetti P, Langella M, Cogliandro A, MArangi GF, Perrella E, Rabitti C, Mellone P, Baldi A (2005): Cutaneous lymphoadenoma, a rare clinicopathological entity. Journal of Experimental & Clinical Cancer Research 24: 207-209.

38) Abbate A, Bussani R, Biondi-Zoccai GL, Santini D, Petrolini A, De Giorgio F, Vasaturo F, Scarpa S, Severino A, Liuzzo G, Leone AM, Baldi F, Sinagra G, Vetrovec GW, Crea F, Biasucci LM,  Baldi A (2005): Infarcì-related artery occlusion, tissue markers of ischemia, and increased apoptosis in the peri-infarct viable myocardium. European Heart Journal                                            

39) Campioni M, Santini D, Tonini G, Murace R, Dragonetti E, Spugnino EP, Baldi A (2005): Role of Apaf-1, a key regulator of apoptosis, in melanoma progression and chemoresistance. Experimental Dermatology 14: 811-818    

40) Spugnini EP, Dragonetti E, Murace R, Cassandro R, Groeger AM, Di Marino MP, Baldi A (2005): Spontaneous intestinal melanoma in dogs. In Vivo                                 
 
41) Spugnini EP, Esposito V, Groeger AM, Cassandro R, Onori N, Chirianni A, Baldi A (2006): Effect of indinavir in a preliminary phase I study on dogs with stage III splenic Hemangiosarcoma. In Vivo 20: 125-128

42) Abbate A, De Falco M, Morales C, Gelpi RJ, Prisco M, De Luca A, Palleiro J, Fedele V, Feroce F, Baldi F, Vetrovec GW, Baldi A (2007): Electron microscopy characterization of cardiomyocyte apoptosis in ischemic heart disease.  International Journal of Cardiology  (in corso di stampa)                

43) Spugnini E.P., Dragonetti E., Vincenzi B., Onori N., Citro G., Baldi A (2006): Pulse-mediated chemotherapy enhances local control and survival in a spontaneous canine model of primari mucosal melanoma. Melanoma Research 16: 23-27                                            

44) Esposito V, Palescandolo E, Spugnini EP, Montesarchio V, De Luca A, Cardillo I, Cortese G, Baldi A, Chirianni A (2006): Evaluation of antitumoral properties of the protease inhibitor indinavir in a murine model of hepatocarcinoma. Clinical Cancer Research 12: 2634-2639                        

45) Spugnini EP, Baldi A,, Vincenzi B, Bongiorni F, Bellelli C, Citro G, Porrello A (2006): Intraoperative versus postoperative electrochemotherapy in high grade soft tissue sarcomas. A preliminary study in a spontaneous feline model. Cancer Chemotherapy Pharmacology 59: 375-381                    

46) Spugnini EP, Bosari S, Citro G, Lorenzon I, Cognetti F, Baldi A (2006): Human malignant mesothelioma: Molecular mechanisms of pathogenesis and  progression. International Journal of Biochemistry and Cell Biology 38: 2000-2004.                                    

47) Chien J, Aletti G, Baldi A,, Catalano A, Muretto P, Keeney GL, Kalli KR, Staub J, Ehrmann M, Cliby WA, Lee JK, Bible KC, Hartmann LC, Kaufmann SH, Shridhar V (2006): Serine proteae HtrA1 modulates chemotherapy-induced cytoxicity. Journal of Clinical Investigation 116: 1994-2004                    

48) Baldi A, Spugnini EP (2006): Thoracic hemangioperycitoma in a cat. The Veterinary Record 159: 598-600    

49) Baldi A, Colloca E, Spugnini EP (2006): Lomustine for the treatment of gastrointestinal mast cell tumor in a dog. The Journal of Small Animals Practice 47: 465-467                             

50) Fortunato L, Baldi A,  Farina M,  Campioni M,  Amini M,  Piro FR, Costarelli L,  Pompili P,  Vitelli CE (2006): Bone marrow and sentinel lymph node biopsy in patients with breast cancer: from staging to ultrastaging. Journal of Experimental and Clinical Cancer Research 25: 207-213.                        

51) Spugnini EP, Vincenzi B, Baldi F, Citro G, Baldi A (2006): Adjuvant electrochemotherapy for the treatment of incompletely resected canine mast cell tumors. Anticancer Research 26: 4585-4589            

52) Esposito V, Campioni M, De Luca A, Spugnini EP, Baldi F, Cassandro R, Mancini A, Vincenzi B, Groeger A, Caputi M, Baldi A (2006): Analysys of HtrA1 serine protease expression in human lung cancer  Anticancer Research 26: 3455-3460                                            

53) Angiero F, Mellone P, Baldi A, Stefani M (2006): Osteoblastoma of the jaws. Report of two cases and review of the literature. In Vivo 20: 665-670                                    
 
54) Spugnini EP, Cardillo I, Verdina A , Crispi S, Saviozzi S, Calogero R, Nebbioso A, Altucci L, Cortese G, Galati R, Chien J, Shridhar V, Vincenzi B, Citro G, Cognetti F, Sacchi A, Baldi A (2006): Piroxicam and cisplatin in a mouse model of peritoneal mesothelioma. Clinical Cancer Research 12: 6133-6143                

55) Spugnini EP, Filippini M, Romani L, Dotsinski I, Mudrov N, Baroni A, Rocco E, Lieta MT, Montesarchio V, Cassandro R, Citro G, Baldi A (2007): Local Control and Distant Metastasis After Electrochemotherapy of a Canine Anal Melanoma. In Vivo (in corso di stampa)                            

56) Delfino S, Toto V, Brunetti B, Di Marino MP, Baldi A, Persichetti P (2007): Poroid hidroadenoma, a case report. In Vivo (in corso di stampa)                                    

57) Baldi A, De Crescenzo V, Giordano DR, Lamberti R, Perna A, Picone C, Lucariello A, Feroce F, Grattacapo S, De Luca A (2007): Cystic nephroma, report of a case and review of the literature. In Vivo (in corso di stampa)

58) Severino A, Campioni M, Straino S, Salloum FN, Schmidt N, Herbrand U, Frede S, Toietta G, Di Rocco G, Bussani R, Silvestri F, Piro M, Liuzzo G, Biasucci LM, Mellone  P, Feroce F, Capogrossi M, Baldi F, Fandrey J, Ehrmann M, Crea F, Abbate A, Baldi A (2007): Identification of protein disulfide isomerase (PDI) as a cardiomyocyte survival factor during the development of human ischemic cardiomyopathy. Journal of American College of Cardiology 42: 1714    

59) Spugnini EP, Citro G, Mellone P, Dotsinsky I, Mudrov N, Baldi A (2007): Electrochemotherapy for localized lymphoma: a preliminary study in companion animals. Journal of Experimental and Clinical Cancer Research 26: 515-518.                                    

60) Manente L,  Perna A,  Buommino E,  Altucci L, Lucariello A, Citro G,  Baldi A,  Iaquinto G,  Tufano MA,  De Luca A (2007): The Helicobacter Pylori’s protein VacA has direct effects on the regulation of cell cycle and apoptosis in gastric epithelial cells. Journal of Cellular Physiology (in corso di stampa)                

61) Spugnini EP, Citro G, Dotsinsky I, Mudron N, Mellone P, Baldi A (2007): Ganglioneuroblastoma in a cat: a rare neoplasm treated with electrochemotherapy. The Veterinary Journal (in corso di stampa)        

62) Spugnini EP, Vincenzi B, Citro G, Tonini G, Dotsinsky I, Mudron N, Baldi A (2007): Electrochemotherapy for the treatment of squamous cell carcinoma in cats: a preliminary report. The Veterinary Journal (in corso di stampa)
                                                
63) Spugnini EP, Citro G, D’Avino A, Baldi A (2007): Potential role of electrochemotherapy for the treatment of soft tissue sarcoma: first insights from preclinical studies in animals. International Journal of Biochemistry and Cell Biology (in corso di stampa)                                        

64) Spugnini EP, Baldi F, Mellone P, Feroce F, D’Avino A, Bonetto F, Vincenzi B, Citro G, Baldi A  (2007): Patterns of tumor response in canine and feline cancer patients treated with electrochemotherapy: preclinical data for the standardization of this treatment in pets and humans. Journal of Translational Medicine (in corso di stampa)